Ancestors in Our Genome

Ancestors in Our Genome PDF Author: Eugene E. Harris (Professor)
Publisher: Oxford University Press, USA
ISBN: 0199978034
Category : Science
Languages : en
Pages : 226

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Book Description
Geneticist Eugene Harris presents us with the complete and up-to-date account of the evolution of the human genome.

Before the Dawn

Before the Dawn PDF Author: Nicholas Wade
Publisher: Penguin
ISBN: 110105283X
Category : Science
Languages : en
Pages : 320

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Book Description
“Meaty, well-written.” —Kirkus Reviews “Timely and informative.” —The New York Times Book Review “By far the best book I have ever read on humanity’s deep history.” —E. O. Wilson, biologist and author of The Ants and On Human Nature Nicholas Wade’s articles are a major reason why the science section has become the most popular, nationwide, in the New York Times. In his groundbreaking Before the Dawn, Wade reveals humanity’s origins as never before—a journey made possible only recently by genetic science, whose incredible findings have answered such questions as: What was the first human language like? How large were the first societies, and how warlike were they? When did our ancestors first leave Africa, and by what route did they leave? By eloquently solving these and numerous other mysteries, Wade offers nothing less than a uniquely complete retelling of a story that began 500 centuries ago.

Genome: The Autobiography of a Species in 23 Chapters

Genome: The Autobiography of a Species in 23 Chapters PDF Author: Matt Ridley
Publisher: HarperCollins UK
ISBN: 0007381840
Category : Science
Languages : en
Pages : 352

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Book Description
The most important investigation of genetic science since The Selfish Gene, from the author of the critically acclaimed and best-selling The Red Queen and The Origins of Virtue.

Methods and Algorithms for Inference Problems in Population Genetics

Methods and Algorithms for Inference Problems in Population Genetics PDF Author: Jingwen Pei
Publisher:
ISBN:
Category : Demography
Languages : en
Pages : 74

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Book Description
Inference of population history is a central problem of population genetics. The advent of large genetic data brings us not only opportunities on developing more accurate methods for inference problems, but also computational challenges. Thus, we aim at developing accurate method and fast algorithm for problems in population genetics. Inference of admixture proportions is a classical statistical problem. We particularly focus on the problem of ancestry inference for ancestors. Standard methods implicitly assume that both parents of an individual have the same admixture fraction. However, this is rarely the case in real data. We develop a Hidden Markov Model (HMM) framework for estimating the admixture proportions of the immediate ancestors of an individual, id est a type of appropriation of an individual's admixture proportions into further subsets of ancestral proportions in the ancestors. Based on a genealogical model for admixture tracts, we develop an efficient algorithm for computing the sampling probability of the genome from a single individual, as a function of the admixture proportions of the ancestors of this individual. We show that the distribution and lengths of admixture tracts in a genome contain information about the admixture proportions of the ancestors of an individual. This allows us to perform probabilistic inference of admixture proportions of ancestors only using the genome of an extant individual. To better understand population, we further study the species delimitation problem. It is a problem of determining the boundary between population and species. We propose a classification-based method to assign a set of populations to a number of species. Our new method uses summary statistics generated from genetic data to classify pairwise populations as either 'same species' or 'different species'. We show that machine learning can be used for species delimitation and scaled for large genomic data. It can also outperform Bayesian approaches, especially when gene flow involves in the evolutionary process.

Tears of the Cheetah

Tears of the Cheetah PDF Author: Dr. Stephen J. O'Brien
Publisher: St. Martin's Griffin
ISBN: 1250102316
Category : Science
Languages : en
Pages : 304

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Book Description
The history of life on Earth is dominated by extinction events so numerous that over 99.9% of the species ever to have existed are gone forever. If animals could talk, we would ask them to recall their own ancestries, in particular the secrets as to how they avoided almost inevitable annihilation in the face of daily assaults by predators, climactic cataclysms, deadly infections and innate diseases. In Tears of the Cheetah, medical geneticist and conservationist Stephen J. O'Brien narrates fast-moving science adventure stories that explore the mysteries of survival among the earth's most endangered and beloved wildlife. Here we uncover the secret histories of exotic species such as Indonesian orangutans, humpback whales, and the imperiled cheetah-the world's fastest animal which nonetheless cannot escape its own genetic weaknesses. Among these genetic detective stories we also discover how the Serengeti lions have lived with FIV (the feline version of HIV), where giant pandas really come from, how bold genetic action pulled the Florida panther from the edge of extinction, how the survivors of the medieval Black Death passed on a genetic gift to their descendents, and how mapping the genome of the domestic cat solved a murder case in Canada. With each riveting account of animal resilience and adaptation, a remarkable parallel in human medicine is drawn, adding yet another rationale for species conservation-mining their genomes for cures to our own fatal diseases. Tears of the Cheetah offers a fascinating glimpse of the insight gained when geneticists venutre into the wild.

Attack Surface

Attack Surface PDF Author: Cory Doctorow
Publisher: Tor Books
ISBN: 1250757525
Category : Fiction
Languages : en
Pages : 386

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Book Description
Cory Doctorow's Attack Surface is a standalone novel set in the world of New York Times bestsellers Little Brother and Homeland. Most days, Masha Maximow was sure she'd chosen the winning side. In her day job as a counterterrorism wizard for an transnational cybersecurity firm, she made the hacks that allowed repressive regimes to spy on dissidents, and manipulate their every move. The perks were fantastic, and the pay was obscene. Just for fun, and to piss off her masters, Masha sometimes used her mad skills to help those same troublemakers evade detection, if their cause was just. It was a dangerous game and a hell of a rush. But seriously self-destructive. And unsustainable. When her targets were strangers in faraway police states, it was easy to compartmentalize, to ignore the collateral damage of murder, rape, and torture. But when it hits close to home, and the hacks and exploits she’s devised are directed at her friends and family--including boy wonder Marcus Yallow, her old crush and archrival, and his entourage of naïve idealists--Masha realizes she has to choose. And whatever choice she makes, someone is going to get hurt. At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.

The Deeper Genome

The Deeper Genome PDF Author: John Parrington
Publisher: Oxford University Press
ISBN: 0192552473
Category : Science
Languages : en
Pages : 368

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Book Description
Over a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought — just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportion of DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'? Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact of its 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes of Neanderthals as well as that of chimps about the development of our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

A Brief History of Everyone Who Ever Lived

A Brief History of Everyone Who Ever Lived PDF Author: Adam Rutherford
Publisher: Hachette UK
ISBN: 0297609394
Category : Science
Languages : en
Pages : 432

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Book Description
'A brilliant, authoritative, surprising, captivating introduction to human genetics. You'll be spellbound' Brian Cox This is a story about you. It is the history of who you are and how you came to be. It is unique to you, as it is to each of the 100 billion modern humans who have ever drawn breath. But it is also our collective story, because in every one of our genomes we each carry the history of our species - births, deaths, disease, war, famine, migration and a lot of sex. In this captivating journey through the expanding landscape of genetics, Adam Rutherford reveals what our genes now tell us about human history, and what history can now tell us about our genes. From Neanderthals to murder, from redheads to race, dead kings to plague, evolution to epigenetics, this is a demystifying and illuminating new portrait of who we are and how we came to be. *** 'A thoroughly entertaining history of Homo sapiens and its DNA in a manner that displays popular science writing at its best' Observer 'Magisterial, informative and delightful' Peter Frankopan 'An extraordinary adventure...From the Neanderthals to the Vikings, from the Queen of Sheba to Richard III, Rutherford goes in search of our ancestors, tracing the genetic clues deep into the past' Alice Roberts

The Human Story

The Human Story PDF Author: Christopher Sloan
Publisher:
ISBN: 9780605023390
Category :
Languages : en
Pages :

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Book Description


Ancestors in Our Genome

Ancestors in Our Genome PDF Author: Eugene E. Harris (Professor)
Publisher: Oxford University Press, USA
ISBN: 0199978034
Category : Science
Languages : en
Pages : 226

View

Book Description
Geneticist Eugene Harris presents us with the complete and up-to-date account of the evolution of the human genome.

Ancestors in our genome

Ancestors in our genome PDF Author: Eugene E. Harris
Publisher:
ISBN:
Category :
Languages : es
Pages : 397

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Book Description


Before the Dawn

Before the Dawn PDF Author: Nicholas Wade
Publisher: Penguin
ISBN: 110105283X
Category : Science
Languages : en
Pages : 320

View

Book Description
“Meaty, well-written.” —Kirkus Reviews “Timely and informative.” —The New York Times Book Review “By far the best book I have ever read on humanity’s deep history.” —E. O. Wilson, biologist and author of The Ants and On Human Nature Nicholas Wade’s articles are a major reason why the science section has become the most popular, nationwide, in the New York Times. In his groundbreaking Before the Dawn, Wade reveals humanity’s origins as never before—a journey made possible only recently by genetic science, whose incredible findings have answered such questions as: What was the first human language like? How large were the first societies, and how warlike were they? When did our ancestors first leave Africa, and by what route did they leave? By eloquently solving these and numerous other mysteries, Wade offers nothing less than a uniquely complete retelling of a story that began 500 centuries ago.

Genome: The Autobiography of a Species in 23 Chapters

Genome: The Autobiography of a Species in 23 Chapters PDF Author: Matt Ridley
Publisher: HarperCollins UK
ISBN: 0007381840
Category : Science
Languages : en
Pages : 352

View

Book Description
The most important investigation of genetic science since The Selfish Gene, from the author of the critically acclaimed and best-selling The Red Queen and The Origins of Virtue.

Methods and Algorithms for Inference Problems in Population Genetics

Methods and Algorithms for Inference Problems in Population Genetics PDF Author: Jingwen Pei
Publisher:
ISBN:
Category : Demography
Languages : en
Pages : 74

View

Book Description
Inference of population history is a central problem of population genetics. The advent of large genetic data brings us not only opportunities on developing more accurate methods for inference problems, but also computational challenges. Thus, we aim at developing accurate method and fast algorithm for problems in population genetics. Inference of admixture proportions is a classical statistical problem. We particularly focus on the problem of ancestry inference for ancestors. Standard methods implicitly assume that both parents of an individual have the same admixture fraction. However, this is rarely the case in real data. We develop a Hidden Markov Model (HMM) framework for estimating the admixture proportions of the immediate ancestors of an individual, id est a type of appropriation of an individual's admixture proportions into further subsets of ancestral proportions in the ancestors. Based on a genealogical model for admixture tracts, we develop an efficient algorithm for computing the sampling probability of the genome from a single individual, as a function of the admixture proportions of the ancestors of this individual. We show that the distribution and lengths of admixture tracts in a genome contain information about the admixture proportions of the ancestors of an individual. This allows us to perform probabilistic inference of admixture proportions of ancestors only using the genome of an extant individual. To better understand population, we further study the species delimitation problem. It is a problem of determining the boundary between population and species. We propose a classification-based method to assign a set of populations to a number of species. Our new method uses summary statistics generated from genetic data to classify pairwise populations as either 'same species' or 'different species'. We show that machine learning can be used for species delimitation and scaled for large genomic data. It can also outperform Bayesian approaches, especially when gene flow involves in the evolutionary process.

Tears of the Cheetah

Tears of the Cheetah PDF Author: Dr. Stephen J. O'Brien
Publisher: St. Martin's Griffin
ISBN: 1250102316
Category : Science
Languages : en
Pages : 304

View

Book Description
The history of life on Earth is dominated by extinction events so numerous that over 99.9% of the species ever to have existed are gone forever. If animals could talk, we would ask them to recall their own ancestries, in particular the secrets as to how they avoided almost inevitable annihilation in the face of daily assaults by predators, climactic cataclysms, deadly infections and innate diseases. In Tears of the Cheetah, medical geneticist and conservationist Stephen J. O'Brien narrates fast-moving science adventure stories that explore the mysteries of survival among the earth's most endangered and beloved wildlife. Here we uncover the secret histories of exotic species such as Indonesian orangutans, humpback whales, and the imperiled cheetah-the world's fastest animal which nonetheless cannot escape its own genetic weaknesses. Among these genetic detective stories we also discover how the Serengeti lions have lived with FIV (the feline version of HIV), where giant pandas really come from, how bold genetic action pulled the Florida panther from the edge of extinction, how the survivors of the medieval Black Death passed on a genetic gift to their descendents, and how mapping the genome of the domestic cat solved a murder case in Canada. With each riveting account of animal resilience and adaptation, a remarkable parallel in human medicine is drawn, adding yet another rationale for species conservation-mining their genomes for cures to our own fatal diseases. Tears of the Cheetah offers a fascinating glimpse of the insight gained when geneticists venutre into the wild.

Attack Surface

Attack Surface PDF Author: Cory Doctorow
Publisher: Tor Books
ISBN: 1250757525
Category : Fiction
Languages : en
Pages : 386

View

Book Description
Cory Doctorow's Attack Surface is a standalone novel set in the world of New York Times bestsellers Little Brother and Homeland. Most days, Masha Maximow was sure she'd chosen the winning side. In her day job as a counterterrorism wizard for an transnational cybersecurity firm, she made the hacks that allowed repressive regimes to spy on dissidents, and manipulate their every move. The perks were fantastic, and the pay was obscene. Just for fun, and to piss off her masters, Masha sometimes used her mad skills to help those same troublemakers evade detection, if their cause was just. It was a dangerous game and a hell of a rush. But seriously self-destructive. And unsustainable. When her targets were strangers in faraway police states, it was easy to compartmentalize, to ignore the collateral damage of murder, rape, and torture. But when it hits close to home, and the hacks and exploits she’s devised are directed at her friends and family--including boy wonder Marcus Yallow, her old crush and archrival, and his entourage of naïve idealists--Masha realizes she has to choose. And whatever choice she makes, someone is going to get hurt. At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.

The Deeper Genome

The Deeper Genome PDF Author: John Parrington
Publisher: Oxford University Press
ISBN: 0192552473
Category : Science
Languages : en
Pages : 368

View

Book Description
Over a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought — just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportion of DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'? Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact of its 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes of Neanderthals as well as that of chimps about the development of our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

A Brief History of Everyone Who Ever Lived

A Brief History of Everyone Who Ever Lived PDF Author: Adam Rutherford
Publisher: Hachette UK
ISBN: 0297609394
Category : Science
Languages : en
Pages : 432

View

Book Description
'A brilliant, authoritative, surprising, captivating introduction to human genetics. You'll be spellbound' Brian Cox This is a story about you. It is the history of who you are and how you came to be. It is unique to you, as it is to each of the 100 billion modern humans who have ever drawn breath. But it is also our collective story, because in every one of our genomes we each carry the history of our species - births, deaths, disease, war, famine, migration and a lot of sex. In this captivating journey through the expanding landscape of genetics, Adam Rutherford reveals what our genes now tell us about human history, and what history can now tell us about our genes. From Neanderthals to murder, from redheads to race, dead kings to plague, evolution to epigenetics, this is a demystifying and illuminating new portrait of who we are and how we came to be. *** 'A thoroughly entertaining history of Homo sapiens and its DNA in a manner that displays popular science writing at its best' Observer 'Magisterial, informative and delightful' Peter Frankopan 'An extraordinary adventure...From the Neanderthals to the Vikings, from the Queen of Sheba to Richard III, Rutherford goes in search of our ancestors, tracing the genetic clues deep into the past' Alice Roberts

The Human Story

The Human Story PDF Author: Christopher Sloan
Publisher:
ISBN: 9780605023390
Category :
Languages : en
Pages :

View

Book Description