Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System PDF Author: J. David Sweatt
Publisher: Academic Press
ISBN: 0123944058
Category : Science
Languages : en
Pages : 374

Get Book

Book Description
Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system. Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions. Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia. BMA Medical Book Awards 2014 - Highly Commended, Neurology, British Medical Association BMA Medical Book Awards 2014 - First Prize, Neurology, British Medical Association 2013 PROSE Award winner for Best in Reference Works and Best Single Volume Reference in Science from the Association of American Publishers Presents a unified view of epigenetic mechanisms from behavior to genes and everything in between Discusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientists Provides numerous practical examples for the new investigator to facilitate implementation of research in neuroepigenetics

Transcriptional and Translational Regulation of Stem Cells

Transcriptional and Translational Regulation of Stem Cells PDF Author: Gary Hime
Publisher: Springer Science & Business Media
ISBN: 9400766211
Category : Medical
Languages : en
Pages : 371

Get Book

Book Description
This volume describes the latest findings on transcriptional and translational regulation of stem cells. Both transcriptional activators and repressors have been shown to be crucial for the maintenance of the stem cell state. A key element of stem cell maintenance is repression of differentiation factors or developmental genes – achieved transcriptionally, epigenetically by the Polycomb complex, and post-transcriptionally by RNA-binding proteins and microRNAs. This volume takes two approaches to this topic – (1) illustrating the general principles outlined above through a series of different stem cell examples – embryonic, iPS and adult stem cells, and (2) describing several molecular families that have been shown to have roles in regulation of multiple stem cell populations.

iPSCs for Modeling Central Nervous System Disorders, Volume 6

iPSCs for Modeling Central Nervous System Disorders, Volume 6 PDF Author: Alexander Birbrair
Publisher: Academic Press
ISBN: 032385642X
Category : Science
Languages : en
Pages : 352

Get Book

Book Description
The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs for Modeling Central Nervous System Disorders, Volume 6 addresses how induced pluripotent stem cells can be used to model various CNS disorders. Somatic cells can be reprogrammed into Induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several CNS diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different CNS pathologies. Further insights into these mechanisms will have important implications for our understanding of CNS disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several CNS disorders. This volume will cover what we know so far about the use of iPSCs to model different CNS disorders, such as: Alzheimer’s disease, Autism, Amyotrophic Lateral Sclerosis, Schizophrenia, Fragile X Syndrome, Spinal Muscular Atrophy, Rett Syndrome, Angelman syndrome, Parkinson`s Disease, Leber Hereditary Optic Neuropathy, Anorexia Nervosa, and more. The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and neuroscience; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology and its application in neurobiology. Covers the following CNS diseases: Alzheimer’s disease, Autism, Amyotrophic Lateral Sclerosis, Schizophrenia, Fragile X Syndrome, Spinal Muscular Atrophy, Rett Syndrome, Angelman syndrome, Parkinson`s Disease, Leber Hereditary Optic Neuropathy, Anorexia Nervosa, and more. Contains description of cutting-edge research on the development of disease-specific human pluripotent stem cells. These cells allow us to study cellular and molecular processes involved in several CNS human diseases.

Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development

Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development PDF Author: Constanze Bonifer
Publisher: Springer Science & Business Media
ISBN: 3642451985
Category : Medical
Languages : en
Pages : 416

Get Book

Book Description
During vertebrate hematopoiesis many specialized cell types are formed with vastly different functions such as B cells, T cells, granulocytes, macrophages, erythrocytes and megakaryocytes. To tightly control the enormous proliferative potential of developing blood cells, an intricately balanced signaling and transcription network has evolved that ensures that the different cell types are formed at the right time and in the right numbers. Intricate regulatory mechanisms ensure that blood cells function properly and have a determined life span. Moreover, in the adaptive immune system, long-lived memory cells have evolved that ensure that when pathogens have been seen once they will never cause a problem again. In this book we will therefore make a journey from asking how more primitive organisms use the epigenetic regulatory machinery to balance growth with differentiation control towards digging deep into what controls the function of specialized cells of the human immune system. We will first discover that flies make blood but exist without blood vessels, why fish make blood cells in the kidney and which precise genetic circuitries are required for these developmental pathways. We will then learn the regulatory principles that drive the differentiation of mature blood cells from stem cells and what controls their function in mammals. In the process, we will find out what unites hematopoietic stem cells and endothelial cells. Finally, we will shed light on the molecular mechanisms that either alter hematopoietic cell differentiation or lead to the development of cells with impaired function.

Investigating the Role of Histone Variant H3.3 in Mouse Neural Stem Cell Differentiation Into Neural Cell Types

Investigating the Role of Histone Variant H3.3 in Mouse Neural Stem Cell Differentiation Into Neural Cell Types PDF Author: Allison Wagner
Publisher:
ISBN:
Category :
Languages : en
Pages : 66

Get Book

Book Description
Chromatin is a DNA-protein complex, composed largely of histone proteins. Changes in chromatin structure and composition influence gene expression throughout the genome. These chromatin and transcriptional changes are largely regulated by epigenetic factors including histone modification. In mice, histone variant H3.3 is encoded by two genes, H3f3a and H3f3b. Unlike canonical histones, H3.3 is expressed and deposited onto chromatin throughout the cell cycle and is associated with both transcriptionally active and poised genes. Replacement of canonical histone H3 with H3.3 may lead to functional differences in cell behavior. For instance, H3.3 is required for normal murine development, as studies have shown that loss of H3.3 can cause strong deleterious phenotypes. Furthermore, mutations of H3.3 particularly in cells during development of the central nervous system lead to childhood brain tumors. Better treatments for neurological diseases and these pediatric brain cancers represent a current unmet clinical need. Stem cell research is a promising field in regenerative medicine that may provide new treatments for developmentally related diseases, including neurological disorders. Stem cells are unique because they are able to self renew and differentiate into different cell types. H3.3 has been found to regulate stem cell characteristics and we hypothesize it serves a key role in neural stem cell (NSC) differentiation. A better understanding of the mechanisms of H3.3 function in regulating gene expression is necessary in order to develop safe stem cell therapies including the use of NSC, which could facilitate the development of new brain cancer therapies. In learning more about H3.3, we studied both of its genes, H3f3a and H3f3b, which encode for the same protein. To test our hypothesis and determine the role of H3.3 in NSC, we examined the effect of H3f3a and H3f3b mouse NSC knockouts both in naïve cells and during differentiation. Differentiation towards glial cells is generally favored in both knockout lines, implicating a strong role for H3.3 in cell fate control. We also found evidence of H3.3 coding gene compensation during late differentiation in H3f3b knockout NSCs in the form of elevated H3f3a. Increased protein levels of H3.3 relative to total H3, H3K4me3 and H3K27me3 in differentiated NSCs could indicate a role for H3.3 in chromatin and epigenetic cellular functions. We theorize that cleavage of H3.3 protein is initiated during differentiation, leading potentially to cellular senescence and impaired development. Finally we generated a potential double loss of function approach for H3f3a and H3f3b in NSCs and plan to further study the effect of H3.3 on differentiation, without the confounding effects of H3.3 coding gene compensation.

Regenerative Medicine - from Protocol to Patient

Regenerative Medicine - from Protocol to Patient PDF Author: Gustav Steinhoff
Publisher: Springer
ISBN: 3319275836
Category : Science
Languages : en
Pages : 373

Get Book

Book Description
Regenerative medicine is the main field of groundbreaking medical development and therapy using knowledge from developmental and stem cell biology, as well as advanced molecular and cellular techniques. This collection of volumes on Regenerative Medicine: From Protocol to Patient, aims to explain the scientific knowledge and emerging technology, as well as the clinical application in different organ systems and diseases. International leading experts from all over the world describe the latest scientific and clinical knowledge of the field of regenerative medicine. The process of translating science of laboratory protocols into therapies is explained in sections on regulatory, ethical and industrial issues. This collection is organized into five volumes: (1) Biology of Tissue Regeneration, (2) Stem Cell Science and Technology, (3) Tissue Engineering, Biomaterials and Nanotechnology, (4) Regenerative Therapies I, and (5) Regenerative Therapies II. The textbook gives the student, the researcher, the health care professional, the physician and the patient a complete survey on the current scientific basis, therapeutical protocols, clinical translation and practiced therapies in regenerative medicine. Volume 1 contains eleven chapters addressing the latest basic science knowledge on the “Biology of Tissue Regeneration”. The principles of cell regeneration control by extracellular matrix and the biology of stem cell niches are explained. Depicted are the principles of molecular mechanisms controlling asymmetric cell division, stem cell differentiation, developmental and regenerative biology, epigenetic and genetic control as well as mathematical modelling for cell fate prediction. Regenerative biology of stem cells in the central nervous and cardiovascular systems leading to complex tissue regeneration in the model species axolotl and zebrafish, as well as the impact of immune signalling on nuclear reprogramming are outlined. These up to date accounts gives the readers advanced insights into the biological principles of the regenerative processes in stem cells, tissues and organisms.

The Inductive Brain in Development and Evolution

The Inductive Brain in Development and Evolution PDF Author: Nelson R. Cabej
Publisher: Academic Press
ISBN: 0323851665
Category : Science
Languages : en
Pages : 290

Get Book

Book Description
The Inductive Brain in Development and Evolution provides readers with a substantial biological education on animal nervous systems and their role in the development, adaptation, homeostasis, and evolution of species. The book begins by delving into the embryonic development of the brain and then discusses epigenetic information and neural activity post-birth. It then analyzes the inductive brain’s neural and brain control of such factors like myogenesis, bone development, sensory organs, metamorphosis in vertebrates and invertebrates, and wing development in insects. The book closes with an examination of phenotypic evolution in neural control, mechanisms, and drivers of animal brains. The Inductive Brain in Development and Evolution will offer evolutionary biologists, specifically those researching development, adaptation, and evolution of animals, a comprehensive text that covers a variety of valuable topics. Presents the first book devoted to the inductive role of the brain in development, in adaptation, and in the evolution processes in animals Examines the central nervous system (CNS) from embryonic to adult life stages Provides detailed evidence to investigate the role of the CNS in molding animal morphology and life histories

Epigenetics

Epigenetics PDF Author: Benedikt Hallgrímsson
Publisher: Univ of California Press
ISBN: 0520267095
Category : Science
Languages : en
Pages : 459

Get Book

Book Description
“If you want to understand evolution, you need to understand the murky world of epigenetics. A hearty congratulations should be paid to Hallgrimsson and Hall, who provide reliable and steady illumination.”-Bernard Wood, Center for the Advanced Study of Hominid Paleobiology, George Washington University

Epigenetic Gene Regulation in Mouse Embryonic Stem Cells and the Developing Central Nervous System

Epigenetic Gene Regulation in Mouse Embryonic Stem Cells and the Developing Central Nervous System PDF Author: Shaun David Fouse
Publisher:
ISBN:
Category :
Languages : en
Pages : 316

View

Book Description


Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System PDF Author: J. David Sweatt
Publisher: Academic Press
ISBN: 0123944058
Category : Science
Languages : en
Pages : 374

View

Book Description
Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system. Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions. Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia. BMA Medical Book Awards 2014 - Highly Commended, Neurology, British Medical Association BMA Medical Book Awards 2014 - First Prize, Neurology, British Medical Association 2013 PROSE Award winner for Best in Reference Works and Best Single Volume Reference in Science from the Association of American Publishers Presents a unified view of epigenetic mechanisms from behavior to genes and everything in between Discusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientists Provides numerous practical examples for the new investigator to facilitate implementation of research in neuroepigenetics

Transcriptional and Translational Regulation of Stem Cells

Transcriptional and Translational Regulation of Stem Cells PDF Author: Gary Hime
Publisher: Springer Science & Business Media
ISBN: 9400766211
Category : Medical
Languages : en
Pages : 371

View

Book Description
This volume describes the latest findings on transcriptional and translational regulation of stem cells. Both transcriptional activators and repressors have been shown to be crucial for the maintenance of the stem cell state. A key element of stem cell maintenance is repression of differentiation factors or developmental genes – achieved transcriptionally, epigenetically by the Polycomb complex, and post-transcriptionally by RNA-binding proteins and microRNAs. This volume takes two approaches to this topic – (1) illustrating the general principles outlined above through a series of different stem cell examples – embryonic, iPS and adult stem cells, and (2) describing several molecular families that have been shown to have roles in regulation of multiple stem cell populations.

Epigenetic Mechanisms of Neurogenesis in the Developing Neocortex

Epigenetic Mechanisms of Neurogenesis in the Developing Neocortex PDF Author: Magdalena Götz
Publisher: Frontiers Media SA
ISBN: 288971778X
Category : Science
Languages : en
Pages :

View

Book Description


iPSCs for Modeling Central Nervous System Disorders, Volume 6

iPSCs for Modeling Central Nervous System Disorders, Volume 6 PDF Author: Alexander Birbrair
Publisher: Academic Press
ISBN: 032385642X
Category : Science
Languages : en
Pages : 352

View

Book Description
The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs for Modeling Central Nervous System Disorders, Volume 6 addresses how induced pluripotent stem cells can be used to model various CNS disorders. Somatic cells can be reprogrammed into Induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several CNS diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different CNS pathologies. Further insights into these mechanisms will have important implications for our understanding of CNS disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several CNS disorders. This volume will cover what we know so far about the use of iPSCs to model different CNS disorders, such as: Alzheimer’s disease, Autism, Amyotrophic Lateral Sclerosis, Schizophrenia, Fragile X Syndrome, Spinal Muscular Atrophy, Rett Syndrome, Angelman syndrome, Parkinson`s Disease, Leber Hereditary Optic Neuropathy, Anorexia Nervosa, and more. The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and neuroscience; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology and its application in neurobiology. Covers the following CNS diseases: Alzheimer’s disease, Autism, Amyotrophic Lateral Sclerosis, Schizophrenia, Fragile X Syndrome, Spinal Muscular Atrophy, Rett Syndrome, Angelman syndrome, Parkinson`s Disease, Leber Hereditary Optic Neuropathy, Anorexia Nervosa, and more. Contains description of cutting-edge research on the development of disease-specific human pluripotent stem cells. These cells allow us to study cellular and molecular processes involved in several CNS human diseases.

Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development

Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development PDF Author: Constanze Bonifer
Publisher: Springer Science & Business Media
ISBN: 3642451985
Category : Medical
Languages : en
Pages : 416

View

Book Description
During vertebrate hematopoiesis many specialized cell types are formed with vastly different functions such as B cells, T cells, granulocytes, macrophages, erythrocytes and megakaryocytes. To tightly control the enormous proliferative potential of developing blood cells, an intricately balanced signaling and transcription network has evolved that ensures that the different cell types are formed at the right time and in the right numbers. Intricate regulatory mechanisms ensure that blood cells function properly and have a determined life span. Moreover, in the adaptive immune system, long-lived memory cells have evolved that ensure that when pathogens have been seen once they will never cause a problem again. In this book we will therefore make a journey from asking how more primitive organisms use the epigenetic regulatory machinery to balance growth with differentiation control towards digging deep into what controls the function of specialized cells of the human immune system. We will first discover that flies make blood but exist without blood vessels, why fish make blood cells in the kidney and which precise genetic circuitries are required for these developmental pathways. We will then learn the regulatory principles that drive the differentiation of mature blood cells from stem cells and what controls their function in mammals. In the process, we will find out what unites hematopoietic stem cells and endothelial cells. Finally, we will shed light on the molecular mechanisms that either alter hematopoietic cell differentiation or lead to the development of cells with impaired function.

Investigating the Role of Histone Variant H3.3 in Mouse Neural Stem Cell Differentiation Into Neural Cell Types

Investigating the Role of Histone Variant H3.3 in Mouse Neural Stem Cell Differentiation Into Neural Cell Types PDF Author: Allison Wagner
Publisher:
ISBN:
Category :
Languages : en
Pages : 66

View

Book Description
Chromatin is a DNA-protein complex, composed largely of histone proteins. Changes in chromatin structure and composition influence gene expression throughout the genome. These chromatin and transcriptional changes are largely regulated by epigenetic factors including histone modification. In mice, histone variant H3.3 is encoded by two genes, H3f3a and H3f3b. Unlike canonical histones, H3.3 is expressed and deposited onto chromatin throughout the cell cycle and is associated with both transcriptionally active and poised genes. Replacement of canonical histone H3 with H3.3 may lead to functional differences in cell behavior. For instance, H3.3 is required for normal murine development, as studies have shown that loss of H3.3 can cause strong deleterious phenotypes. Furthermore, mutations of H3.3 particularly in cells during development of the central nervous system lead to childhood brain tumors. Better treatments for neurological diseases and these pediatric brain cancers represent a current unmet clinical need. Stem cell research is a promising field in regenerative medicine that may provide new treatments for developmentally related diseases, including neurological disorders. Stem cells are unique because they are able to self renew and differentiate into different cell types. H3.3 has been found to regulate stem cell characteristics and we hypothesize it serves a key role in neural stem cell (NSC) differentiation. A better understanding of the mechanisms of H3.3 function in regulating gene expression is necessary in order to develop safe stem cell therapies including the use of NSC, which could facilitate the development of new brain cancer therapies. In learning more about H3.3, we studied both of its genes, H3f3a and H3f3b, which encode for the same protein. To test our hypothesis and determine the role of H3.3 in NSC, we examined the effect of H3f3a and H3f3b mouse NSC knockouts both in naïve cells and during differentiation. Differentiation towards glial cells is generally favored in both knockout lines, implicating a strong role for H3.3 in cell fate control. We also found evidence of H3.3 coding gene compensation during late differentiation in H3f3b knockout NSCs in the form of elevated H3f3a. Increased protein levels of H3.3 relative to total H3, H3K4me3 and H3K27me3 in differentiated NSCs could indicate a role for H3.3 in chromatin and epigenetic cellular functions. We theorize that cleavage of H3.3 protein is initiated during differentiation, leading potentially to cellular senescence and impaired development. Finally we generated a potential double loss of function approach for H3f3a and H3f3b in NSCs and plan to further study the effect of H3.3 on differentiation, without the confounding effects of H3.3 coding gene compensation.

Regenerative Medicine - from Protocol to Patient

Regenerative Medicine - from Protocol to Patient PDF Author: Gustav Steinhoff
Publisher: Springer
ISBN: 3319275836
Category : Science
Languages : en
Pages : 373

View

Book Description
Regenerative medicine is the main field of groundbreaking medical development and therapy using knowledge from developmental and stem cell biology, as well as advanced molecular and cellular techniques. This collection of volumes on Regenerative Medicine: From Protocol to Patient, aims to explain the scientific knowledge and emerging technology, as well as the clinical application in different organ systems and diseases. International leading experts from all over the world describe the latest scientific and clinical knowledge of the field of regenerative medicine. The process of translating science of laboratory protocols into therapies is explained in sections on regulatory, ethical and industrial issues. This collection is organized into five volumes: (1) Biology of Tissue Regeneration, (2) Stem Cell Science and Technology, (3) Tissue Engineering, Biomaterials and Nanotechnology, (4) Regenerative Therapies I, and (5) Regenerative Therapies II. The textbook gives the student, the researcher, the health care professional, the physician and the patient a complete survey on the current scientific basis, therapeutical protocols, clinical translation and practiced therapies in regenerative medicine. Volume 1 contains eleven chapters addressing the latest basic science knowledge on the “Biology of Tissue Regeneration”. The principles of cell regeneration control by extracellular matrix and the biology of stem cell niches are explained. Depicted are the principles of molecular mechanisms controlling asymmetric cell division, stem cell differentiation, developmental and regenerative biology, epigenetic and genetic control as well as mathematical modelling for cell fate prediction. Regenerative biology of stem cells in the central nervous and cardiovascular systems leading to complex tissue regeneration in the model species axolotl and zebrafish, as well as the impact of immune signalling on nuclear reprogramming are outlined. These up to date accounts gives the readers advanced insights into the biological principles of the regenerative processes in stem cells, tissues and organisms.

The Inductive Brain in Development and Evolution

The Inductive Brain in Development and Evolution PDF Author: Nelson R. Cabej
Publisher: Academic Press
ISBN: 0323851665
Category : Science
Languages : en
Pages : 290

View

Book Description
The Inductive Brain in Development and Evolution provides readers with a substantial biological education on animal nervous systems and their role in the development, adaptation, homeostasis, and evolution of species. The book begins by delving into the embryonic development of the brain and then discusses epigenetic information and neural activity post-birth. It then analyzes the inductive brain’s neural and brain control of such factors like myogenesis, bone development, sensory organs, metamorphosis in vertebrates and invertebrates, and wing development in insects. The book closes with an examination of phenotypic evolution in neural control, mechanisms, and drivers of animal brains. The Inductive Brain in Development and Evolution will offer evolutionary biologists, specifically those researching development, adaptation, and evolution of animals, a comprehensive text that covers a variety of valuable topics. Presents the first book devoted to the inductive role of the brain in development, in adaptation, and in the evolution processes in animals Examines the central nervous system (CNS) from embryonic to adult life stages Provides detailed evidence to investigate the role of the CNS in molding animal morphology and life histories

Epigenetics

Epigenetics PDF Author: Benedikt Hallgrímsson
Publisher: Univ of California Press
ISBN: 0520267095
Category : Science
Languages : en
Pages : 459

View

Book Description
“If you want to understand evolution, you need to understand the murky world of epigenetics. A hearty congratulations should be paid to Hallgrimsson and Hall, who provide reliable and steady illumination.”-Bernard Wood, Center for the Advanced Study of Hominid Paleobiology, George Washington University