Epigenetics in Health and Disease

Epigenetics in Health and Disease PDF Author: Igor Kovalchuk
Publisher: FT Press
ISBN: 0132599511
Category : Education
Languages : en
Pages : 608

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Book Description
This is the first comprehensive, authoritative, and easy-to-understand introduction to modern epigenetics. Authored by two active researchers in the field, it introduces key concepts one step at a time, enabling students at all levels to benefit from it. The authors begin by presenting a historical overview that places epigenetics in context, and makes it clear that the field is not (as some presume) completely new. Next, they introduce and explain key epigenetic mechanisms, and discuss the roles these mechanisms may play in inheritance, organism development, health and disease, behavior, evolution, ecology, and the interaction of individual organisms with their environments. Coverage includes: non-coding RNAs in each kingdom; allelic interactions; CRYSPR; gene silencing; epigenetics of germline and epigenetic memory; epigenetic regulation of genome stability and plant stress response; and much more. The authors conclude by offering significant new insights into how knowledge of epigenetics and epigenomics may promote the development of technologies and solutions in areas ranging from behavioral neuroscience to cancer treatment, toxicology to the development of hardier crops.

Epigenetics in Health and Disease

Epigenetics in Health and Disease PDF Author:
Publisher: Academic Press
ISBN: 9780443186691
Category : Science
Languages : en
Pages : 0

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Book Description
Progress in Molecular Biology and Translational Science, Epigenetics in Health and Disease Volume 197, highlights new advances in the field, with this new volume presenting interesting chapters on Epigenetics in Health and Disease. Each chapter is written by an international board of authors.

Molecular mechanisms and physiology of disease

Molecular mechanisms and physiology of disease PDF Author: Nilanjana Maulik
Publisher: Springer
ISBN: 9781493946235
Category : Medical
Languages : en
Pages : 505

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Book Description
In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.

Epigenetics and Epigenomics in Health and Disease

Epigenetics and Epigenomics in Health and Disease PDF Author: Kylan Russell
Publisher:
ISBN: 9781639871971
Category :
Languages : en
Pages : 0

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Book Description
Epigenetics is a branch of biology which deals with the study of heritable phenotype changes that are not associated with the alterations in the DNA sequence. It generally involves the alterations which affect gene expression and activity but it may also include any heritable phenotypic change. These effects on cellular and physiological phenotypic characteristics may be a part of normal development or may result from environmental factors. Epigenomics refers to the study of the epigenome which is the complete set of epigenetic modifications taking place in the genetic material of a cell. These epigenetic modifications are reversible in nature. They affect gene expression without altering the DNA sequence. The book studies, analyses and upholds the pillars of epigenetics and epigenomics and their utmost significance in modern times. It consists of contributions made by international experts. As these fields are emerging at a fast pace, this book will help the readers to better understand their concepts.

Epigenetics in Human Disease

Epigenetics in Human Disease PDF Author: Trygve Tollefsbol
Publisher: Academic Press
ISBN: 012812329X
Category : Medical
Languages : en
Pages : 1110

Get Book

Book Description
Epigenetics in Human Disease, Second Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. In addition to detailing the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, novel epigenetic approaches to treatment are also explored. Fully revised and up-to-date, this new edition discusses topics of current interest in epigenetic research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, and epigenetic mechanisms of imprinting disorders. Further sections explore online epigenetic tools and datasets, early-life programming of epigenetics in age-related diseases, the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer’s disease, respiratory diseases, and many other human maladies. Includes contributions from leading international investigators involved in translational epigenetic research and therapeutic applications Integrates methods and applications with fundamental chapters on epigenetics in human disease, along with an evaluation of recent clinical breakthroughs Presents side-by-side coverage of the basis of epigenetic diseases and treatment pathways Provides a fully revised resource covering current developments, including stem cell epigenetic therapy, the bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, online epigenetic tools and datasets, and more

Epigenetic Epidemiology

Epigenetic Epidemiology PDF Author: Karin B. Michels
Publisher: Springer Nature
ISBN: 3030944751
Category : Electronic books
Languages : en
Pages : 516

Get Book

Book Description
Now in its second edition, this book provides a state of the art overview on basic concepts of epigenetic epidemiology and a comprehensive review of the rapidly evolving field of human epigenetics. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. Unlike our genetic inheritance, our epigenome is malleable throughout the lifecourse and is shaped by our environmental experiences. Population-based epidemiologic studies increasingly incorporate epigenetic components. These so called epigenome-wide association studies (EWAS) contribute substantially to our understanding of the relevance of epigenetic marks, such as DNA methylation, histone modification, and non-coding RNAs for disease causation. Written by leading experts in the field, the book opens with a comprehensive introduction of the principles of epigenetic epidemiology and discusses challenges in study design, analysis, and interpretation. It summarizes the latest advances in epigenetic laboratory techniques, the influence of age and environmental factors on shaping the epigenome, the epigenetic clock, and the role of epigenetics in the developmental origins hypothesis. The final part focuses on epigenetic epidemiology of various health conditions such as imprinting disorders, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, metabolic disorder and vascular disease, as well as neurodevelopmental and psychiatric disorders. Given its scope, Epigenetic Epidemiology is an indispensable resource for researchers working in the field of human epigenetics.

The Epigenome and Developmental Origins of Health and Disease

The Epigenome and Developmental Origins of Health and Disease PDF Author: Cheryl S Rosenfeld
Publisher: Academic Press
ISBN: 0128016728
Category : Science
Languages : en
Pages : 560

Get Book

Book Description
The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring. The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring. It is increasingly becoming apparent that even subtle changes in the mother’s diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples. Informs how everyday choices pregnant women make can impact child development Ties together how in utero environmental changes may be inducing epigenetic changes in the offspring leading to overlapping phenotypes regardless of the initial insult (toxic, nutrition, or stress) Includes a boxed-in area in each chapter for further references and resources to keep up with the field Features video interviews with the authors and other key leaders in the field

Environmental Epigenomics in Health and Disease

Environmental Epigenomics in Health and Disease PDF Author: Randy L Jirtle
Publisher: Springer
ISBN: 9783642427282
Category : Medical
Languages : en
Pages : 302

Get Book

Book Description
There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.

The Science of Epigenetics

The Science of Epigenetics PDF Author: Onur Karakoç
Publisher: Bookademy
ISBN:
Category : Science
Languages : en
Pages : 19

Get Book

Book Description
The Science of Epigenetics - A Comprehensive Overview As you embark on your journey through the world of epigenetics, you will discover the incredible ways in which gene expression can be influenced by a variety of factors, from environmental exposures to lifestyle choices. Epigenetics is a rapidly growing field that is revolutionizing our understanding of how genes are regulated, and the implications of this research are vast. In this book, you will learn about the mechanisms of epigenetic regulation, the role of epigenetics in human health and disease, and the exciting possibilities for epigenetic therapies. You will also explore the complex interplay between genetics and epigenetics, and how this interaction affects development and evolution. The field of epigenetics is constantly evolving, and this book provides a comprehensive overview of the current state of our knowledge. I hope it serves as a valuable resource as you delve deeper into the fascinating world of epigenetics.

Medical Epigenetics

Medical Epigenetics PDF Author: Trygve Tollefsbol
Publisher: Academic Press
ISBN: 0128032405
Category : Science
Languages : en
Pages : 944

Get Book

Book Description
Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine

Epigenetics in Health and Disease

Epigenetics in Health and Disease PDF Author: Igor Kovalchuk
Publisher: FT Press
ISBN: 0132599511
Category : Education
Languages : en
Pages : 608

View

Book Description
This is the first comprehensive, authoritative, and easy-to-understand introduction to modern epigenetics. Authored by two active researchers in the field, it introduces key concepts one step at a time, enabling students at all levels to benefit from it. The authors begin by presenting a historical overview that places epigenetics in context, and makes it clear that the field is not (as some presume) completely new. Next, they introduce and explain key epigenetic mechanisms, and discuss the roles these mechanisms may play in inheritance, organism development, health and disease, behavior, evolution, ecology, and the interaction of individual organisms with their environments. Coverage includes: non-coding RNAs in each kingdom; allelic interactions; CRYSPR; gene silencing; epigenetics of germline and epigenetic memory; epigenetic regulation of genome stability and plant stress response; and much more. The authors conclude by offering significant new insights into how knowledge of epigenetics and epigenomics may promote the development of technologies and solutions in areas ranging from behavioral neuroscience to cancer treatment, toxicology to the development of hardier crops.

Epigenetics in Health and Disease

Epigenetics in Health and Disease PDF Author:
Publisher: Academic Press
ISBN: 9780443186691
Category : Science
Languages : en
Pages : 0

View

Book Description
Progress in Molecular Biology and Translational Science, Epigenetics in Health and Disease Volume 197, highlights new advances in the field, with this new volume presenting interesting chapters on Epigenetics in Health and Disease. Each chapter is written by an international board of authors.

Molecular mechanisms and physiology of disease

Molecular mechanisms and physiology of disease PDF Author: Nilanjana Maulik
Publisher: Springer
ISBN: 9781493946235
Category : Medical
Languages : en
Pages : 505

View

Book Description
In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.

Epigenetics and Epigenomics in Health and Disease

Epigenetics and Epigenomics in Health and Disease PDF Author: Kylan Russell
Publisher:
ISBN: 9781639871971
Category :
Languages : en
Pages : 0

View

Book Description
Epigenetics is a branch of biology which deals with the study of heritable phenotype changes that are not associated with the alterations in the DNA sequence. It generally involves the alterations which affect gene expression and activity but it may also include any heritable phenotypic change. These effects on cellular and physiological phenotypic characteristics may be a part of normal development or may result from environmental factors. Epigenomics refers to the study of the epigenome which is the complete set of epigenetic modifications taking place in the genetic material of a cell. These epigenetic modifications are reversible in nature. They affect gene expression without altering the DNA sequence. The book studies, analyses and upholds the pillars of epigenetics and epigenomics and their utmost significance in modern times. It consists of contributions made by international experts. As these fields are emerging at a fast pace, this book will help the readers to better understand their concepts.

Epigenetics in Human Disease

Epigenetics in Human Disease PDF Author: Trygve Tollefsbol
Publisher: Academic Press
ISBN: 012812329X
Category : Medical
Languages : en
Pages : 1110

View

Book Description
Epigenetics in Human Disease, Second Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. In addition to detailing the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, novel epigenetic approaches to treatment are also explored. Fully revised and up-to-date, this new edition discusses topics of current interest in epigenetic research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, and epigenetic mechanisms of imprinting disorders. Further sections explore online epigenetic tools and datasets, early-life programming of epigenetics in age-related diseases, the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer’s disease, respiratory diseases, and many other human maladies. Includes contributions from leading international investigators involved in translational epigenetic research and therapeutic applications Integrates methods and applications with fundamental chapters on epigenetics in human disease, along with an evaluation of recent clinical breakthroughs Presents side-by-side coverage of the basis of epigenetic diseases and treatment pathways Provides a fully revised resource covering current developments, including stem cell epigenetic therapy, the bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, online epigenetic tools and datasets, and more

Epigenetic Epidemiology

Epigenetic Epidemiology PDF Author: Karin B. Michels
Publisher: Springer Nature
ISBN: 3030944751
Category : Electronic books
Languages : en
Pages : 516

View

Book Description
Now in its second edition, this book provides a state of the art overview on basic concepts of epigenetic epidemiology and a comprehensive review of the rapidly evolving field of human epigenetics. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. Unlike our genetic inheritance, our epigenome is malleable throughout the lifecourse and is shaped by our environmental experiences. Population-based epidemiologic studies increasingly incorporate epigenetic components. These so called epigenome-wide association studies (EWAS) contribute substantially to our understanding of the relevance of epigenetic marks, such as DNA methylation, histone modification, and non-coding RNAs for disease causation. Written by leading experts in the field, the book opens with a comprehensive introduction of the principles of epigenetic epidemiology and discusses challenges in study design, analysis, and interpretation. It summarizes the latest advances in epigenetic laboratory techniques, the influence of age and environmental factors on shaping the epigenome, the epigenetic clock, and the role of epigenetics in the developmental origins hypothesis. The final part focuses on epigenetic epidemiology of various health conditions such as imprinting disorders, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, metabolic disorder and vascular disease, as well as neurodevelopmental and psychiatric disorders. Given its scope, Epigenetic Epidemiology is an indispensable resource for researchers working in the field of human epigenetics.

The Epigenome and Developmental Origins of Health and Disease

The Epigenome and Developmental Origins of Health and Disease PDF Author: Cheryl S Rosenfeld
Publisher: Academic Press
ISBN: 0128016728
Category : Science
Languages : en
Pages : 560

View

Book Description
The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring. The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring. It is increasingly becoming apparent that even subtle changes in the mother’s diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples. Informs how everyday choices pregnant women make can impact child development Ties together how in utero environmental changes may be inducing epigenetic changes in the offspring leading to overlapping phenotypes regardless of the initial insult (toxic, nutrition, or stress) Includes a boxed-in area in each chapter for further references and resources to keep up with the field Features video interviews with the authors and other key leaders in the field

Environmental Epigenomics in Health and Disease

Environmental Epigenomics in Health and Disease PDF Author: Randy L Jirtle
Publisher: Springer
ISBN: 9783642427282
Category : Medical
Languages : en
Pages : 302

View

Book Description
There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.

The Science of Epigenetics

The Science of Epigenetics PDF Author: Onur Karakoç
Publisher: Bookademy
ISBN:
Category : Science
Languages : en
Pages : 19

View

Book Description
The Science of Epigenetics - A Comprehensive Overview As you embark on your journey through the world of epigenetics, you will discover the incredible ways in which gene expression can be influenced by a variety of factors, from environmental exposures to lifestyle choices. Epigenetics is a rapidly growing field that is revolutionizing our understanding of how genes are regulated, and the implications of this research are vast. In this book, you will learn about the mechanisms of epigenetic regulation, the role of epigenetics in human health and disease, and the exciting possibilities for epigenetic therapies. You will also explore the complex interplay between genetics and epigenetics, and how this interaction affects development and evolution. The field of epigenetics is constantly evolving, and this book provides a comprehensive overview of the current state of our knowledge. I hope it serves as a valuable resource as you delve deeper into the fascinating world of epigenetics.

Medical Epigenetics

Medical Epigenetics PDF Author: Trygve Tollefsbol
Publisher: Academic Press
ISBN: 0128032405
Category : Science
Languages : en
Pages : 944

View

Book Description
Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine